The estimated glomerular filtration rate (eGFR) is a key indicator of kidney function, measuring how effectively your kidneys filter waste from the blood. A low eGFR can signal impaired kidney function or chronic kidney disease (CKD). Understanding the factors that contribute to a decreased eGFR is essential for early intervention and management.
Common Causes of Low eGFR
- Diabetes MellitusChronic high blood sugar levels can damage the blood vessels in the kidneys, leading to diabetic nephropathy—a leading cause of reduced eGFR.
- Hypertension (High Blood Pressure)Elevated blood pressure can cause wear and tear on the blood vessels in the kidneys, impairing their filtering ability over time.
- GlomerulonephritisThis inflammation of the kidney’s filtering units (glomeruli) can result from infections or autoimmune diseases, leading to decreased kidney function.
- Polycystic Kidney DiseaseAn inherited disorder characterized by the growth of numerous cysts in the kidneys, which can enlarge and impair function, reducing eGFR.
- Age-Related DeclineeGFR naturally decreases with age, even in individuals without kidney disease. This decline is due to the gradual loss of nephrons, the kidney’s filtering units.
- Obstruction of the Urinary TractConditions such as kidney stones, enlarged prostate, or tumors can block urine flow, leading to back pressure and kidney damage, thereby lowering eGFR.
- Certain MedicationsLong-term use of nephrotoxic drugs, including some nonsteroidal anti-inflammatory drugs (NSAIDs) and certain antibiotics, can harm kidney tissue and reduce eGFR.
- DehydrationSevere dehydration can lead to kidney injury and a lower GFR. However, it isn’t a typical cause of chronic kidney disease and low GFR.
Natural Ways to Increase eGFR Levels
Addressing the underlying causes of a low eGFR can help improve kidney function. For comprehensive, step-by-step methods to enhance your eGFR naturally, explore our guide on how to increase eGFR levels naturally.
Note: Always consult with a healthcare professional before making significant lifestyle or dietary changes, especially if you have existing health conditions.