Chronic Kidney Disease (CKD) is a progressive condition characterized by the gradual loss of kidney function over time. A crucial metric in assessing kidney health is the estimated Glomerular Filtration Rate (eGFR), which measures how effectively the kidneys filter waste from the blood. Understanding the connection between CKD and eGFR is essential for early detection and management of kidney health.
What is eGFR?
The eGFR is a calculated value based on factors such as age, sex, body size, and serum creatinine levels—a waste product from muscle metabolism. It provides an estimate of the rate at which the kidneys are filtering blood, expressed in milliliters per minute per 1.73 square meters of body surface area (mL/min/1.73 m²). A normal eGFR is typically greater than 90 mL/min/1.73 m², indicating healthy kidney function.
eGFR and CKD Stages
CKD is categorized into five stages based on eGFR values:
- Stage 1: eGFR ≥ 90 mL/min/1.73 m² (normal kidney function but with evidence of kidney damage)
- Stage 2: eGFR 60–89 mL/min/1.73 m² (mildly reduced kidney function)
- Stage 3: eGFR 30–59 mL/min/1.73 m² (moderately reduced kidney function)
- Stage 4: eGFR 15–29 mL/min/1.73 m² (severely reduced kidney function)
- Stage 5: eGFR < 15 mL/min/1.73 m² (kidney failure)
As CKD progresses, eGFR decreases, reflecting worsening kidney function. Regular monitoring of eGFR helps in assessing the progression of CKD and planning appropriate interventions.
Factors Leading to Decreased eGFR
Several factors can contribute to a declining eGFR, including:
- Diabetes Mellitus: Chronic high blood sugar levels can damage kidney tissues, leading to reduced filtration capacity.
- Hypertension (High Blood Pressure): Elevated blood pressure can cause wear and tear on blood vessels in the kidneys, impairing their function.
- Glomerulonephritis: Inflammation of the kidney’s filtering units can lead to scarring and decreased filtration ability.
- Polycystic Kidney Disease: An inherited condition characterized by fluid-filled cysts in the kidneys, which can interfere with normal function.
- Obstruction of the Urinary Tract: Conditions like kidney stones or an enlarged prostate can block urine flow, causing back pressure and kidney damage.
Natural Ways to Improve eGFR Levels
Addressing the underlying causes of a low eGFR can help improve kidney function. For comprehensive, step-by-step methods to enhance your eGFR naturally, explore our guide on how to increase eGFR levels naturally.
Note: Always consult with a healthcare professional before making significant lifestyle or dietary changes, especially if you have existing health conditions.